Varieties of the state of exchange of nitrogenous metabolites (creatinine, urea, uric acid and bilirubin) and their immune accompaniment at rats

Background. Earlier we found that even in intact rats, certain parameters of nitrogenous metabolism and immunity fluctuate a fairly wide range, which further expands cases prolonged water loads. The links between the individual were revealed. Based on this, aim this study was to create groups are homogeneous metabolism, followed by search for characteristic immunity. Material methods. Experiment performed 60 healthy female Wistar both loaded with different mineral waters. plasma levels urinary excretion metabolites (creatinine, urea, uric acid bilirubin) determined. Immune status assessed thymocytogram, splenocytogram, blood leukocytogram immunocytogram, as well phagocytosis neutrophils monocytes. Results. features members most numerous (29 animals) first cluster moderately elevated urea upper borderline creatinineemia combination lower uricemia. In third (22 animals), all seven range normal. contrast, rats second (n=9) have significantly increased creatinine excretion, Each is accompanied specific constellation immune parameters. overall accuracy classification 95%. Conclusion. variety states exchange constellations